Name | Image | Tier | Pool | Description | Flavor |
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Book of Revelations | | Common | | 6 charges. When fully charged, right-click to gain barricade and 10 soul heart. | A part of bookworm. |
How to Jump | | Common | | Negate damage 10% of the time. Right-click to jump. | A part of bookworm. |
Swallowed Penny | | Common | | Whenever you lose HP, gain 7 Gold. | The keeper's swallowed penny! It's game over. |
The Bean | | Common | | 1 charge. When fully charged, right-click to apply 5 poison to ALL enemies. | Toot on command. |
The Book Of Belial | | Common | | 3 charges. When fully charged, right-click to gain 5 strength. | In fact, it is called the book of Pilates |
Anarchist Cookbook | | Uncommon | | 3 charges. Right-click to give 6 The Bomb effect, which deals damage to ALL opposing characters later, to the player and ALL enemies randomly. Your The Bomb effect will be triggered first. | A part of bookworm. |
Bible | | Uncommon | | 6 charges. When fully charged, right-click to gain 6 Flight. | Want to defeat the heart immediately? Not a chance. |
Book of Shadows | | Uncommon | | 3 charges. When fully charged, right-click to prevent all damages for the next 2 turns. | A part of bookworm. |
Dead eye | | Uncommon | | Gain 1 strength whenever you play attacks on the same target in a row in the same turn. The strength gained will be removed at the end of the turn and when you attack different enemies. | Accuracy brings strength! |
Doctor's Remote | | Uncommon | | 2 charges. When fully charged, right-click to add a [Epic attack +2] to your hand. | Use it as a bomb |
Gnawed Leaf | | Uncommon | | After three consecutive turns without playing any cards, the player will be immune to all damages until a card is played. | One two three wood people. |
Magic Fingers | | Uncommon | | Right-click to pay 1 Gold to deal 1 damage to ALL enemies. Whenever you use this relic, increase the cost and damage of this relic by 1. | Pay to play |
Satanic Bible | | Uncommon | | 6 charges. When fully charged, right-click to gain barricade, 30 block, and 10 black heart. | A part of bookworm. |
Sharp Plug | | Uncommon | | Right-Click to lose half HP(Max 50, Min 15),select a chargeable relic which is 0 charge,and charge to full charge. | Awesome Combo! |
Spire's pills | | Uncommon | | Pills may drop at the end of each battle. The pills with the same color will have the same effect. (If you save and quit at the pill reward screen, pill's effect still works.) | Open your mouth to take the medicine. |
The Necronomicon | | Uncommon | | 6 Charges. When fully charged, right-click to deal 40 damage to ALL enemies. | This Necronomicon is not the Necronomicon |
Unicorn Stump | | Uncommon | | 1 charge. When fully charged, right-click to immune to all damages this turn, and you cannot play any cards this turn. Cannot be used after playing any cards. | It stands still like a mountain! |
Blank Card | | Rare | | 6 charges. When fully charged, right-click to select a card from your hand and play it once at the start of each following turns. | Hoho! Easy game! |
Blood Donation Machine | | Rare | | Right-click to donate 1 HP for 20 Gold (10%), 10 Gold (30%), 5 Gold (30%), or 1 Gold (30%). It has a 3% probability of exlosion every time it is used. Upon explosion, gain 7 Max HP or get Blood Donation Bag. You cannot donate blood during boss fights. | Is this a German machine? |
D4 | | Rare | | 6 charges,roll all relics you obtained,replace every relic to the random relic with same relic tier. | ROLL! |
D6 | | Rare | | 6 charges. When fully charged, right-click to re-roll the shop, relic that elite dropped, the treasure chest and the boss treasure chest. | The D6! It's game over |
Damocles | | Rare | | An extra relic is gained after battle, but have chance to die when you lose HP fromenemies,10% at the beginning and gain 4% chance whenever you gain damage. If your next hp loss will cause death, it will begin to pulse to remind you. When resurrected, lose this relic. | A king’sfortune… but at what cost? |
Diplopia | | Rare | | Right-click to choose and copy an existing relic. (Copying Diplopia will get a Diplopia, but new one won't work.) | Double discounts with Diplopia is also available at the Spire! |
Eden's Blessing | | Rare | | At the start of each battle, gain 1 Strength, Dexterity, or Focus randomly. You start you next game with a random rare relic. | The blessing from Eden |
Forget Me Now | | Rare | | Only be used once,right-click to go back to the first floor of current dungeon(at BossTreasureRoom,you go to next dungeon as normal; at boss room, nothing will happen.). | go back |
Guppy's Head | | Rare | | 1 charge. When fully charged, right-click to summon a fly that deals damage to enemies. | A part of Guppy |
Guppy's Paw | | Rare | | Right click to trade 1 Max Hp for 3 SoulHeart. | A part of Guppy. |
Guppy's Tail | | Rare | | Little chests are now large chests. | A part of Guppy. |
Leech | | Rare | | Summon a leech at battle start, leech will deal damage and heal for you. | gain blood! |
MONEY = POWER | | Rare | | At the start of each battle, gain Gold / 150 strength. | Gold = Strength |
Poke Go | | Rare | | Right-Click to get a PokeBall(1 cost). PokeBall can catch the monster(not boss) which HP only left 1 or catch 1 HP BOSS at the chance of 15%, and become your pet.(max pet amount = 1) | Gotta catch em... |
Punching Bag | | Rare | | summon a Scape Goat at battle start.Right-Click this relic to get a card to change a enemy's target to Scape Goat | don't hurt me. |
Void | | Rare | | 6 charges, at 2 or 4 or 6 charge can inhale relics from the relic list by right-click, gain 1 charge when inhale relic(cannot inhale the bloom mark, passive relics get random initial attributes, clickable relics get its effect, and gain the effect immediately when full charge), if full charge,right-click can trigger all effect it already gains. | Consume |
Yum Heart | | Rare | | 4 charges. When fully charged, right-click to heal 25 HP. | Miss Mo is really bad! |
AliPay | | Special | | Click to get 500 temporary Gold. You will lose all Gold the next time you lose Gold. This relic is disabled once used until entering the boss room. (Not Isaac related, just remained as the first relic I made) | Money - easy come easy go |
Blood Bag | | Special | | Gain 7 max HP. | Only occurs after Blood Donation Machine crack |
Blood Donation Bag | | Special | | Right-click to donate 1 HP for 10 Gold (20%), 5 Gold (30%), or 1 Gold (50%). You cannot donate blood during boss fights. | The quality is not as good as the Blood Donation Machine |
Dead Cat | | Special | | Upon pick up, reduce your Max HP by 75% and gain 9 lives. When resurrected, heal to full HP. | 9 lives! A part of Guppy |
Guppy's Collar | | Special | | When you would die, heal to 1 HP with 60% of chance. | A part of Guppy. |
Guppy's Hairball | | Special | | At the start of each battle, summon a Hairball that deals damage to enemies. Once per battle, when the Hairball kills an enemy, its Strength is permanently increased by 2. | A part of Guppy. |
Hush's Door | | Special | | The key to Hush. Right click to cancel challenging hush, do it before you enter the second last floor. | Rush! |
Incubus | | Special | | At the start of each battle, summon an Incubus, which, at the end of each turn, plays the last card you played that turn. | Conjoined haven't finished. |
Judas' Shadow | | Special | | After the death, you will resurrect into the shadow of Judah. Max Hp = 1, receive 40 black hearts. gain 15 strength at battle start. | Be stronger! |
Keeper's gift | | Special | | Right-click to use, select and obtain a relic from 3 random Isaac relics. | Select one from three. |
Mega Blast | | Special | | 12 charges. When fully charged, right-click to defeat ALL enemies(by 12 * 500 damage) at battle start for 15 seconds. | RUSH! |
Mom's Knife | | Special | | summon a knife at battle start, left-click and press,release to discharge the knife,knife take damage to the monsters on the way. | take huge damage |
My Shadow | | Special | | When you lose Hp, summon a Charger. | Me! And my shaaaadow! |
Rotten Baby | | Special | | Spawn a fly at turn start. | A nice baby |
Succubus | | Special | | At the beginning of each battle, summon a succubus that moves, deals damage to enemies and gives 1 strength to the player temporarily. | Something fun! |
Isaac's Champion Belt | | Boss | | Gain [E], when you enter monster room,turn ascension level to 20, switch it into elite room with 80% of chance. | Challenging me! |
Magic Mushroom | | Boss | | Upon pick up, gain 7 max HP. At the start of each battle, gain 1 strength, 1 dexterity, 1 focus, 1 plated armor, 1 regeneration, 1 fire breathing, 1 juggernaut, 1 thorns, 1 feel no pain, 1 blur, 1 conserve, and 1 anger. | All stat up. |
9 Volt | | Shop | | Your chargeable relics will gain 1 charge after use. | No effect for one charge relics |
BFFS! | | Shop | | All minions gain 5 strength when they summon. | Best Friends Forever! |
Chaos | | Shop | | Chaos causes relics to be chosen from random item pools. | !!! |
Habit | | Shop | | Add 1 charge to your first chargeable relic which is not full of charge when you lose HP. | You will be glad to see this |
Steam Sale | | Shop | | 50% discount on all products! If you hold a membership card or another Steam Sale at the same time, all products are free! | Double discounts is also available at the Spire! |
The Battery | | Shop | | Chargeable relics get the double charge limit. | Double Charge! |